The effect of ageing on ocular blood flow, oxygen tension and retinal function during and after intraocular pressure elevation

JKH Lim; CTO Nguyen; Z He; AJ Vingrys; BV Bui

Journal article

The effect of ageing on ocular blood flow, oxygen tension and retinal function during and after intraocular pressure elevation

JKH Lim, CTO Nguyen, Z He, AJ Vingrys, BV Bui

Plos One | PUBLIC LIBRARY SCIENCE | Published : 2014

DOI: 10.1371/journal.pone.0098393

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Abstract

Purpose: To investigate the effect of ageing on the recovery of ocular blood flow, intravitreal oxygen tension and retinal function during and after intraocular pressure (IOP) elevation. Methods: Long Evans rats (3- and 14-month-old) underwent acute stepwise IOP elevation from 10 to 120 mmHg (5 mmHg steps each 3 minutes). IOP was then returned to baseline and recovery was monitored for 2 hours. Photopic electroretinograms (ERG) were recorded at each IOP step during stress and at each minute during recovery. Ocular blood flow and vitreal oxygen tension (pO2) were assayed continuously and simultaneously using a combined laser Doppler flow meter (LDF) and an oxygen sensitive fibre-optic probe, ..

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University of Melbourne Researchers

Christine Nguyen Author

Algis Vingrys Author

Bang Bui Author

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Grants

Awarded by National Health and Medical Research Council

Funding Acknowledgements

This study was funded by the National Health and Medical Research Council Project Grant 566570. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.